Article
Control of mouse hepatocyte proliferation and ploidy by p53 and p53ser246 mutation in vivo.
Hepatology (Baltimore, Md.) - 1 Jan 1998
Yin L, Ghebranious N, Chakraborty S, Sheehan C E, Ilic Z, Sell S
Abstract excerpt
The effect of expression of the p53 gene, in the presence or absence of the p53ser246 mutation (p53*), on ploidization (image cytometry), proliferation (expression of proliferating cell nuclear antigen and radioactive thymidine histoautoradiography), and apoptosis (in situ detection of DNA fragments) is determined in hepatocytes of p53-null and p53*-transgenic mice. The mouse p53ser246 mutation is equivalent to...
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