Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.

Nature genetics - 1 May 2013

Wheeler Eleanor, Huang Ni, Bochukova Elena G, Keogh Julia M, Lindsay Sarah, Garg Sumedha, Henning Elana, Blackburn Hannah, Loos Ruth J F, Wareham Nick J, O'Rahilly Stephen, Hurles Matthew E, Barroso Inês, Farooqi I Sadaf

Abstract excerpt

Common and rare variants associated with body mass index (BMI) and obesity account for <5% of the variance in BMI. We performed SNP and copy number variation (CNV) association analyses in 1,509 children with obesity at the extreme tail (>3 s.d. from the mean) of the BMI distribution and 5,380 controls. Evaluation of 29 SNPs (P < 1 × 10(-5)) in an additional 971 severely obese children and 1,990 controls...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Mass Index
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Genome, Human

Share to Genome-Wide Association Study

Share to Obesity

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 23563609
DOI: 10.1038/ng.2607
PMCID: PMC4106235

Genes

LEPR
NEGR1
PACS1
PRKCH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.PMID 23563609Read ↗

Large, rare chromosomal deletions associated with severe early-onset obesity.Semantic proximity Read ↗

Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis.Semantic proximity Read ↗

Large copy-number variations are enriched in cases with moderate to extreme obesity.Semantic proximity Read ↗

A genome-wide study reveals copy number variants exclusive to childhood obesity cases.Semantic proximity Read ↗

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.Semantic proximity Read ↗

Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants.Semantic proximity Read ↗

Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery.Semantic proximity Read ↗

Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity.Semantic proximity Read ↗

Obesity in Children with Leptin Receptor Gene Polymorphisms.Semantic proximity Read ↗

Heterozygous rare genetic variants in non-syndromic early-onset obesitySemantic proximity Read ↗

Copy number variations in "classical" obesity candidate genes are not frequently associated with severe early-onset obesity in children.Semantic proximity Read ↗

Targeted Next-Generation Sequencing of the Leptin-Melanocortin Pathway in Severe Obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.