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Article

Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis.

Human molecular genetics - 15 Feb 2011

Jarick Ivonne, Vogel Carla I G, Scherag Susann, Schäfer Helmut, Hebebrand Johannes, Hinney Anke, Scherag André

Abstract excerpt

Heritability of obesity is substantial and recent meta-analyses of genome-wide association studies (GWASs) have been successful in detecting several robustly associated genomic regions for obesity using single-nucleotide polymorphisms (SNPs). However, taken together, the SNPs explain only a small proportion of the overall heritability. Copy number variations (CNVs) might contribute to the 'missing heritability'....

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Identifiers

PMID: 21131291
DOI: 10.1093/hmg/ddq518
PMCID: PMC3024044

Genes

NEGR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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