Article
Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery.
PloS one - 1 Jan 2013
Mägi Reedik, Manning Sean, Yousseif Ahmed, Pucci Andrea, Santini Ferruccio, Karra Efthimia, Querci Giorgia, Pelosini Caterina, McCarthy Mark I, Lindgren Cecilia M, Batterham Rachel L
Abstract excerpt
The prevalence of severe obesity, defined as body mass index (BMI) ≥ 35.0 kg/m(2), is rising rapidly. Given the disproportionately high health burden and healthcare costs associated with this condition, understanding the underlying aetiology, including predisposing genetic factors, is a biomedical research priority. Previous studies have suggested that severe obesity represents an extreme tail of the population...
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