Article
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.
Nature - 4 Feb 2010
Walters R G, Jacquemont S, Valsesia A, de Smith A J, Martinet D, Andersson J, Falchi M, Chen F, Andrieux J, Lobbens S, Delobel B, Stutzmann F, El-Sayed Moustafa J S, Chèvre J-C, Lecoeur C, Vatin V, Bouquillon S, Buxton J L, Boute O, Holder-Espinasse M, Cuisset J-M, Lemaitre M-P, Ambresin A-E, Brioschi A, Gaillard M, Giusti V, Fellmann F, Ferrarini A, Hadjikhani N, Campion D, Guilmatre A, Goldenberg A, Calmels N, Mandel J-L, Le Caignec C, David A, Isidor B, Cordier M-P, Dupuis-Girod S, Labalme A, Sanlaville D, Béri-Dexheimer M, Jonveaux P, Leheup B, Ounap K, Bochukova E G, Henning E, Keogh J, Ellis R J, Macdermot K D, van Haelst M M, Vincent-Delorme C, Plessis G, Touraine R, Philippe A, Malan V, Mathieu-Dramard M, Chiesa J, Blaumeiser B, Kooy R F, Caiazzo R, Pigeyre M, Balkau B, Sladek R, Bergmann S, Mooser V, Waterworth D, Reymond A, Vollenweider P, Waeber G, Kurg A, Palta P, Esko T, Metspalu A, Nelis M, Elliott P, Hartikainen A-L, McCarthy M I, Peltonen L, Carlsson L, Jacobson P, Sjöström L, Huang N, Hurles M E, O'Rahilly S, Farooqi I S, Männik K, Jarvelin M-R, Pattou F, Meyre D, Walley A J, Coin L J M, Blakemore A I F, Froguel P, Beckmann J S
Abstract excerpt
Obesity has become a major worldwide challenge to public health, owing to an interaction between the Western 'obesogenic' environment and a strong genetic contribution. Recent extensive genome-wide association studies (GWASs) have identified numerous single nucleotide polymorphisms associated with obesity, but these loci together account for only a small fraction of the known heritable component. Thus, the...
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