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Article

Copy number variations in "classical" obesity candidate genes are not frequently associated with severe early-onset obesity in children.

Journal of pediatric endocrinology & metabolism : JPEM - 1 May 2017

Windholz Jan, Kovacs Peter, Schlicke Marina, Franke Christin, Mahajan Anubha, Morris Andrew P, Lemke Johannes R, Klammt Jürgen, Kiess Wieland, Schöneberg Torsten, Pfäffle Roland, Körner Antje

Abstract excerpt

BACKGROUND: Obesity is genetically heterogeneous and highly heritable, although polymorphisms explain the phenotype in only a small proportion of obese children. We investigated the presence of copy number variations (CNVs) in "classical" genes known to be associated with (monogenic) early-onset obesity in children. METHODS: In 194 obese Caucasian children selected for early-onset and severe obesity from our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28593922
DOI: 10.1515/jpem-2016-0435

Genes

SIM1
LEP
LEPR
POMC
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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