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Article

Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants.

PLoS genetics - 1 May 2017

Serra-Juhé Clara, Martos-Moreno Gabriel Á, Bou de Pieri Francesc, Flores Raquel, González Juan R, Rodríguez-Santiago Benjamín, Argente Jesús, Pérez-Jurado Luis A

Abstract excerpt

Obesity is a multifactorial disorder with high heritability (50-75%), which is probably higher in early-onset and severe cases. Although rare monogenic forms and several genes and regions of susceptibility, including copy number variants (CNVs), have been described, the genetic causes underlying the disease still remain largely unknown. We searched for rare CNVs (>100kb in size, altering genes and present in...

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Identifiers

PMID: 28489853
DOI: 10.1371/journal.pgen.1006657
PMCID: PMC5443539

Genes

GRPR
NPY
GRIK1
GRM7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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