Article
An evolutionary shift in the regulation of the Hippo pathway between mice and flies.
Oncogene - 6 Mar 2014
Bossuyt W, Chen C-L, Chen Q, Sudol M, McNeill H, Pan D, Kopp A, Halder G
Abstract excerpt
The Hippo pathway plays a key role in controlling organ growth in many animal species and its deregulation is associated with different types of cancer. Understanding the regulation of the Hippo pathway and discovering upstream regulators is thus a major quest. Interestingly, while the core of the Hippo pathway contains a highly conserved kinase cascade, different components have been identified as upstream...
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