Article
Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 2017
Nishio Miki, Maehama Tomohiko, Goto Hiroki, Nakatani Keisuke, Kato Wakako, Omori Hirofumi, Miyachi Yosuke, Togashi Hideru, Shimono Yohei, Suzuki Akira
Abstract excerpt
The Hippo signaling pathway is a vital suppressor of tumorigenesis that is often inactivated in human cancers. In normal cells, the Hippo pathway is triggered by external forces such as cell crowding, or changes to the extracellular matrix or cell polarity. Once activated, Hippo signaling down-regulates transcription supported by the paralogous cofactors YAP1 and TAZ. The Hippo pathway's functions in normal and...
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