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Article

The WW domain protein Kibra acts upstream of Hippo in Drosophila.

Developmental cell - 16 Feb 2010

Baumgartner Roland, Poernbacher Ingrid, Buser Nathalie, Hafen Ernst, Stocker Hugo

Abstract excerpt

The conserved Hippo kinase pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Whereas the function of the core kinase cascade, consisting of the serine/threonine kinases Hippo and Warts, in phosphorylating and thereby ina...

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Identifiers

PMID: 20159600
DOI: 10.1016/j.devcel.2009.12.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20159600-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The WW domain protein Kibra acts upstream of Hippo in Drosophila.PMID 20159600Read ↗

Kibra is a regulator of the Salvador/Warts/Hippo signaling network.Semantic proximity Read ↗

Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity.Semantic proximity Read ↗

Hippo signaling in Drosophila: recent advances and insights.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read ↗

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.Semantic proximity Read ↗

The bantam microRNA is a target of the hippo tumor-suppressor pathway.Semantic proximity Read ↗

The Drosophila RASSF homolog antagonizes the hippo pathway.Semantic proximity Read ↗

The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila.Semantic proximity Read ↗

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.Semantic proximity Read ↗

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.Semantic proximity Read ↗

The role of the Hippo pathway in human disease and tumorigenesisSemantic proximity Read ↗

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