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Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease

29 May 2013

Abstract excerpt

The vertebrate Fat cadherins comprise a small gene family of four members, Fat1-Fat4, all closely related in structure to Drosophila ft and ft2. Over the past decade, knock-out mouse studies, genetic manipulation, and large sequencing projects has aided our understanding of the function of vertebrate Fat cadherins in tissue development and disease. The majority of studies of this family have focused on Fat1, with...

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PMID: 23720094
DOI: 10.1002/med.21286

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