Article

The Hippo pathway origin and its oncogenic alteration in evolution

2019-11-11

Abstract excerpt

The Hippo pathway is a central regulator of organ size and a key tumor suppressor via coordinating cell proliferation and death. Initially discovered in Drosophila , the Hippo pathway has been implicated as an evolutionarily conserved pathway in mammals; however, how this pathway was evolved to be functional from its origin is still largely unknown. In this study, we traced the Hippo pathway in premetazoan specie...

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Literature Corpus work: d0854c0a-50f3-537e-8975-b25dee133d72
DOI: 10.1101/837500

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