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Article

Prospective study of genomic hypomethylation of leukocyte DNA and colorectal cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2012

Huang Wen-Yi, Su L Joseph, Hayes Richard B, Moore Lee E, Katki Hormuzd A, Berndt Sonja I, Weissfeld Joel L, Yegnasubramanian Srinivasan, Purdue Mark P

Abstract excerpt

BACKGROUND: Systematic genome-wide reductions of methylated cytosine (5-mC) levels have been observed in colorectal cancer tissue and are suspected to play a role in carcinogenesis, possibly as a consequence of inadequate folate intake. Reduced 5-mC levels in peripheral blood leukocytes have been associated with increased risk of colorectal cancer and adenoma in cross-sectional studies. METHODS: To minimize...

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PMID: 23001241
DOI: 10.1158/1055-9965.EPI-12-0700-T
PMCID: PMC3493855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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