Article
Detecting regulatory gene-environment interactions with unmeasured environmental factors.
Bioinformatics (Oxford, England) - 1 Jun 2013
Fusi Nicoló, Lippert Christoph, Borgwardt Karsten, Lawrence Neil D, Stegle Oliver
Abstract excerpt
MOTIVATION: Genomic studies have revealed a substantial heritable component of the transcriptional state of the cell. To fully understand the genetic regulation of gene expression variability, it is important to study the effect of genotype in the context of external factors such as alternative environmental conditions. In model systems, explicit environmental perturbations have been considered for this purpose,...
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