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Article

Joint modelling of confounding factors and prominent genetic regulators provides increased accuracy in genetical genomics studies.

PLoS computational biology - 1 Jan 2012

Fusi Nicoló, Stegle Oliver, Lawrence Neil D

Abstract excerpt

Expression quantitative trait loci (eQTL) studies are an integral tool to investigate the genetic component of gene expression variation. A major challenge in the analysis of such studies are hidden confounding factors, such as unobserved covariates or unknown subtle environmental perturbations. These factors can induce a pronounced artifactual correlation structure in the expression profiles, which may create...

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Share to Algorithms
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Share to Confounding Factors, Epidemiologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22241974
DOI: 10.1371/journal.pcbi.1002330
PMCID: PMC3252274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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