The genomic determinants of genotype × environment interactions in gene expression.

Abstract excerpt

Predicting phenotype from genotype is greatly complicated by the polygenic nature of most traits and by the complex interactions between phenotype and the environment. Here, we review recent whole-genome approaches to understand the underlying principles, mechanisms, and evolutionary impacts of genotype × environment (G×E) interactions, defined as genotype-specific phenotypic responses to different environments....

Topics

• Animals
• Biological Evolution
• Gene Expression
• Gene-Environment Interaction
• Genetic Association Studies
• Genomics
• Genotype
• Humans
• Phenotype
• Promoter Regions, Genetic