Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function.

Nucleic acids research - 1 May 2013

Kononenko Artem V, Lee Nicholas C O, Earnshaw William C, Kouprina Natalay, Larionov Vladimir

Abstract excerpt

Human artificial chromosome (HAC)-based vectors represent an alternative technology for gene delivery and expression with a potential to overcome the problems caused by the use of viral-based vectors. The recently developed alphoid(tetO)-HAC has an advantage over other HAC vectors because it can...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Chromatin
Share to Cricetulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Satellite

Share to Doxycycline

Share to Kinetochores

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 23558748
DOI: 10.1093/nar/gkt205
PMCID: PMC3664798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23558748-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function.PMID 23558748Read ↗

Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.Semantic proximity Read ↗

Rapid assembly of functional modules for generating human artificial chromosome constructs compatible with epigenetic centromere seedingSemantic proximity Read ↗

Stable gene expression from a mammalian artificial chromosome.Semantic proximity Read ↗

Analysis of Complex DNA Rearrangements During Early Stages of HAC FormationSemantic proximity Read ↗

Functional complementation of a genetic deficiency with human artificial chromosomes.Semantic proximity Read ↗

Inducing Specific Chromosome Mis-Segregation in Human CellsSemantic proximity Read ↗

Germline Transmission of a Circular Human Artificial Chromosome in the MouseSemantic proximity Read ↗

Ubiquitous Chromatin Opening Elements (UCOEs) effect on transgene position and expression stability in CHO cells following methotrexate (MTX) amplificationSemantic proximity Read ↗

Protein-only centromeric chromatin assembly streamlines human artificial chromosome formationSemantic proximity Read ↗

Targeted manipulation of heterochromatin rescues MeCP2 Rett mutants and re-establishes higher order chromatin organization.Semantic proximity Read ↗

DASH/Dam1 complex mutants stabilize ploidy by weakening kinetochore-microtubule attachmentsSemantic proximity Read ↗

Epigenetic inactivation and subsequent heterochromatinization of a centromere stabilize dicentric chromosomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.