Article

Germline Transmission of a Circular Human Artificial Chromosome in the Mouse

2022-06-22

Abstract excerpt

Although the structure and function of the alphoid-tetO Human Artificial Chromosome (tetO-HAC) has been previously described in cell culture models and somatically in the mouse, in vivo persistence and stability throughout meiosis and across generations were not evaluated. Here we report germline transmission of a circular tetO-HAC across three mouse generations without observable health or reproductive deficienc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0cc2d424-e1fb-5d9e-b802-ffd203943c73
DOI: 10.1101/2022.06.22.496420

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Germline Transmission of a Circular Human Artificial Chromosome in the MouseDOI 10.1101/2022.06.22.496420Read

Circular DNA in the human germline and its association with recombination.Semantic proximity Read

Exclusive transmission of the embryonic stem cell-derived genome through the mouse germline.Semantic proximity Read

Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function.Semantic proximity Read

LINE-1-derived poly(A) microsatellites undergo rapid shortening and create somatic and germline mosaicism in mice.Semantic proximity Read

Chromosome Transplantation: Opportunities and LimitationsSemantic proximity Read

Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modelingSemantic proximity Read

Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice.Semantic proximity Read

A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm–egg fusionSemantic proximity Read

Construction of Stable Mouse Artificial Chromosome from Native Mouse Chromosome 10 for Generation of Transchromosomic MiceSemantic proximity Read

Functional expression and germline atransmission of a human chromosome fragment in chimaeric miceSemantic proximity Read

Efficient generation of transgenic mice with intact yeast artificial chromosomes by intracytoplasmic sperm injection.Semantic proximity Read

Mouse A9 Cells Containing Single Human Chromosomes for Analysis of Genomic ImprintingSemantic proximity Read