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Article

Stable gene expression from a mammalian artificial chromosome.

EMBO reports - 1 Oct 2001

Grimes B R, Schindelhauer D, McGill N I, Ross A, Ebersole T A, Cooke H J

Abstract excerpt

We have investigated the potential of PAC-based vectors as a route to the incorporation of a gene in a mammalian artificial chromosome (MAC). Previously we demonstrated that a PAC (PAC7c5) containing alpha-satellite DNA generated mitotically stable MACs in human cells. To determine whether a functional HPRT gene could be assembled in a MAC, PAC7c5 was co-transfected with a second PAC containing a 140 kb human...

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Identifiers

PMID: 11571265
DOI: 10.1093/embo-reports/kve187
PMCID: PMC1084075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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