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Article

High-Throughput MICA/B Genotyping of Over Two Million Samples: Workflow and Allele Frequencies.

Frontiers in immunology - 1 Jan 2020

Klussmeier Anja, Massalski Carolin, Putke Kathrin, Schäfer Gesine, Sauter Jürgen, Schefzyk Daniel, Pruschke Jens, Hofmann Jan, Fürst Daniel, Carapito Raphael, Bahram Seiamak, Schmidt Alexander H, Lange Vinzenz

Abstract excerpt

MICA and MICB are ligands of the NKG2D receptor and thereby influence NK and T cell activity. MICA/B gene polymorphisms, expression levels and the amount of soluble MICA/B in the serum have been linked to autoimmune diseases, infections, and cancer. In hematopoietic stem cell transplantation, MICA matching between donor and patient has been correlated with reduced acute and chronic graft-vs.-host disease and...

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Identifiers

PMID: 32153595
DOI: 10.3389/fimmu.2020.00314
PMCID: PMC7047279

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