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Article

Current perspectives on the intensity of natural selection of MHC loci.

Immunogenetics - 1 Jun 2013

Yasukochi Yoshiki, Satta Yoko

Abstract excerpt

Polymorphism of genes in the major histocompatibility complex (MHC) is believed to be maintained by balancing selection. However, direct evidence of selection has proven difficult to demonstrate. In 1994, Satta and colleagues estimated the selection intensity of the human MHC (human leukocyte antigen (HLA)) loci; however, at that time the number of HLA sequences was limited. By comparing five different methods,...

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Identifiers

PMID: 23549729
DOI: 10.1007/s00251-013-0693-x
PMCID: PMC3651823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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