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Article

HLA class I haplotype diversity is consistent with selection for frequent existing haplotypes.

PLoS computational biology - 1 Aug 2017

Alter Idan, Gragert Loren, Fingerson Stephanie, Maiers Martin, Louzoun Yoram

Abstract excerpt

The major histocompatibility complex (MHC) contains the most polymorphic genetic system in humans, the human leukocyte antigen (HLA) genes of the adaptive immune system. High allelic diversity in HLA is argued to be maintained by balancing selection, such as negative frequency-dependent selection or heterozygote advantage. Selective pressure against immune escape by pathogens can maintain appreciable frequencies...

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Identifiers

PMID: 28846675
DOI: 10.1371/journal.pcbi.1005693
PMCID: PMC5590998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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