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Article

Intensity of natural selection at the major histocompatibility complex loci.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 1994

Satta Y, O'hUigin C, Takahata N, Klein J

Abstract excerpt

Long persistence of allelic lineages, prevalence of nonsynonymous over synonymous substitutions in the peptide-binding region (PBR), and deviation from neutrality of the expected gene identity parameter F all indicate indirectly that balancing selection is operating at functional major histocompatibility complex (MHC) loci. Direct demonstrations of the existence of balancing selection at MHC loci are, however,...

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Identifiers

PMID: 8041766
DOI: 10.1073/pnas.91.15.7184
PMCID: PMC44363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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