Intensity of natural selection at the major histocompatibility complex loci.

doi:10.1073/pnas.91.15.7184

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Article

Intensity of natural selection at the major histocompatibility complex loci.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 1994

Satta Y, O'hUigin C, Takahata N, Klein J

Abstract excerpt

Long persistence of allelic lineages, prevalence of nonsynonymous over synonymous substitutions in the peptide-binding region (PBR), and deviation from neutrality of the expected gene identity parameter F all indicate indirectly that balancing selection is operating at functional major histocompa...

Topics

Alleles
Computer Simulation
Humans
Major Histocompatibility Complex
Models, Genetic
Mutation
Selection, Genetic

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