Article
Polymorphism and balancing selection at major histocompatibility complex loci.
Genetics - 1 Apr 1992
Takahata N, Satta Y, Klein J
Abstract excerpt
Amino acid replacements in the peptide-binding region (PBR) of the functional major histocompatibility complex (Mhc) genes appear to be driven by balancing selection. Of the various types of balancing selection, we have examined a model equivalent to overdominance that confers heterozygote advantage. As discussed by A. Robertson, overdominance selection tends to maintain alleles that have more or less the same...
Topics
- Alleles
- Chromosome Mapping
- Computer Simulation
- Genes, MHC Class I
- Genes, MHC Class II
- Genetics, Population
- Major Histocompatibility Complex
- Models, Genetic
- Models, Statistical
- Polymorphism, Genetic
- Protein Binding