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Article

Polymorphism and balancing selection at major histocompatibility complex loci.

Genetics - 1 Apr 1992

Takahata N, Satta Y, Klein J

Abstract excerpt

Amino acid replacements in the peptide-binding region (PBR) of the functional major histocompatibility complex (Mhc) genes appear to be driven by balancing selection. Of the various types of balancing selection, we have examined a model equivalent to overdominance that confers heterozygote advantage. As discussed by A. Robertson, overdominance selection tends to maintain alleles that have more or less the same...

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Identifiers

PMID: 1582567
DOI: 10.1093/genetics/130.4.925
PMCID: PMC1204941

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