Article
A method for estimating the intensity of overdominant selection from the distribution of allele frequencies.
Genetics - 1 Dec 2000
Slatkin M, Muirhead C A
Abstract excerpt
A method is proposed for estimating the intensity of overdominant selection scaled by the effective population size, S = 2Ns, from allele frequencies. The method is based on the assumption that, with strong overdominant selection, allele frequencies are nearly at their deterministic equilibrium values and that, to a first approximation, deviations depend only on S. Simulations verify that reasonably accurate...
Topics
- Algorithms
- Alleles
- Computer Simulation
- Ethnicity
- Gene Frequency
- HLA Antigens
- Histocompatibility Testing
- Humans
- Indians, North American
- Inuit
- Major Histocompatibility Complex
- Models, Genetic
- Selection, Genetic
- Serotyping