Article

Heterogeneity of dN/dS ratios at the classical HLA class I genes over divergence time and across the allelic phylogeny

2014-08-22

Abstract excerpt

The classical class I HLA loci of humans show an excess of nonsynonymous with respect to synonymous substitutions at codons of the antigen recognition site (ARS), a hallmark of adaptive evolution. Additionally, high polymporphism, linkage disequilibrium and disease associations suggest that one or more balancing selection regimes have acted upon these genes. However, several questions about these selective regimes...

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Literature Corpus work: fa3f52cb-153c-5927-9aa2-02c14a5d82cd
DOI: 10.1101/008342

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