Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

How selection shapes variation of the human major histocompatibility complex: a review.

Annals of human genetics - 1 Jan 2001

Meyer D, Thomson G

Abstract excerpt

The nature of polymorphism and molecular sequence variation in the genes of the human major histocompatibility complex (MHC) provides strong support for the idea that these genes are under selection. With the understanding that selection shapes MHC variation new questions have become the focus of study. What is the mode of selection that accounts for MHC polymorphism? Is variation maintained by pathogen pressure...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Haplotypes
Share to Homozygote

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Major Histocompatibility Complex

Share to Models, Genetic

Share to Selection, Genetic

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 11415519
DOI: 10.1046/j.1469-1809.2001.6510001.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How selection shapes variation of the human major histocompatibility complex: a review.PMID 11415519Read ↗

The Nature of Selection on the Major Histocompatibility Complex.Semantic proximity Read ↗

Human MHC architecture and evolution: implications for disease association studies.Semantic proximity Read ↗

The evolutionary ecology of the major histocompatibility complex.Semantic proximity Read ↗

Advances in the Evolutionary Understanding of MHC Polymorphism.Semantic proximity Read ↗

HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.Semantic proximity Read ↗

MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years?Semantic proximity Read ↗

Natural selection at major histocompatibility complex loci of vertebrates.Semantic proximity Read ↗

Sexual selection and the evolutionary dynamics of the major histocompatibility complex.Semantic proximity Read ↗

The major histocompatibility complex and human evolution.Semantic proximity Read ↗

The molecular descent of the major histocompatibility complex.Semantic proximity Read ↗

MHC polymorphism and human origins.Semantic proximity Read ↗

Pathogen-driven selection and worldwide HLA class I diversity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.