Article
Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions.
The Journal of clinical investigation - 1 May 2013
Aziz Athar, Baxter E Joanna, Edwards Carol, Cheong Clara Yujing, Ito Mitsuteru, Bench Anthony, Kelley Rebecca, Silber Yvonne, Beer Philip A, Chng Keefe, Renfree Marilyn B, McEwen Kirsten, Gray Dionne, Nangalia Jyoti, Mufti Ghulam J, Hellstrom-Lindberg Eva, Kiladjian Jean-Jacques, McMullin Mary Frances, Campbell Peter J, Ferguson-Smith Anne C, Green Anthony R
Abstract excerpt
Large regions of recurrent genomic loss are common in cancers; however, with a few well-characterized exceptions, how they contribute to tumor pathogenesis remains largely obscure. Here we identified primate-restricted imprinting of a gene cluster on chromosome 20 in the region commonly deleted in chronic myeloid malignancies. We showed that a single heterozygous 20q deletion consistently resulted in the complete...
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