Challenges and emerging strategies for genome-wide evaluation of loss of imprinting in cancer.

Abstract excerpt

Genomic imprinting is the phenomenon in which only a single allele of a gene is expressed based on its parental origin, thereby deviating from the typical biallelic expression of autosomal genes. It is meticulously controlled by epigenetic mechanisms, particularly DNA methylation. Imprinted loci are crucial for regulating growth during early development, and anomalies in imprinting can lead to congenital...

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