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Article

Multi-Omic Insight Into the Molecular Networks in the Pathogenesis of Coronary Artery Disease.

Journal of the American Heart Association - 1 Apr 2025

Fang Qinghua, Fan Hongdan, Li Qiaoqiao, Zhang Muzi, Zhou Zhengzhong, Du Jianlin, Huang Jing

Abstract excerpt

BACKGROUND: Genome-wide association studies have revealed numerous loci associated with coronary artery disease (CAD). However, some potential causal/risk genes remain unidentified, and causal therapies are lacking. METHODS AND RESULTS: We integrated multi-omics data from gene methylation, expression, and protein levels using summary data-based Mendelian randomization and colocalization analysis. Candidate genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40135555
DOI: 10.1161/JAHA.124.037203
PMCID: PMC12132849

Genes

CAD
TAGLN2
APOB
GIP
DHX58
SWAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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