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Article

PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.

Development (Cambridge, England) - 1 May 2013

Beatty Alexander, Morton Diane G, Kemphues Kenneth

Abstract excerpt

In the one-cell C. elegans embryo, polarity is maintained by mutual antagonism between the anterior cortical proteins PAR-3, PKC-3, PAR-6 and CDC-42, and the posterior cortical proteins PAR-2 and LGL-1 on the posterior cortex. The mechanisms by which these proteins interact to maintain polarity are incompletely understood. In this study, we investigate the interplay among PAR-2, LGL-1, myosin, the anterior PAR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23536568
DOI: 10.1242/dev.088310
PMCID: PMC3631973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.PMID 23536568Read ↗

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Semantic proximity Read ↗

Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.Semantic proximity Read ↗

Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2.Semantic proximity Read ↗

CDC-42 controls early cell polarity and spindle orientation in C. elegans.Semantic proximity Read ↗

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.Semantic proximity Read ↗

CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans.Semantic proximity Read ↗

RAB-5 controls the cortical organization and dynamics of PAR proteins to maintain C. elegans early embryonic polarity.Semantic proximity Read ↗

Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases.Semantic proximity Read ↗

PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.Semantic proximity Read ↗

CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo.Semantic proximity Read ↗

Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.Semantic proximity Read ↗

Functions of the novel RhoGAP proteins RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans.Semantic proximity Read ↗

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