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Article

Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2.

Development (Cambridge, England) - 1 May 2010

Zonies Seth, Motegi Fumio, Hao Yingsong, Seydoux Geraldine

Abstract excerpt

Polarization of the C. elegans zygote is initiated by ECT-2-dependent cortical flows, which mobilize the anterior PAR proteins (PAR-3, PAR-6 and PKC-3) away from the future posterior end of the embryo marked by the sperm centrosome. Here, we demonstrate the existence of a second, parallel and redundant pathway that can polarize the zygote in the absence of ECT-2-dependent cortical flows. This second pathway...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20392744
DOI: 10.1242/dev.045823
PMCID: PMC2860249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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