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Article

RAB-5 controls the cortical organization and dynamics of PAR proteins to maintain C. elegans early embryonic polarity.

PloS one - 1 Jan 2012

Hyenne Vincent, Tremblay-Boudreault Thierry, Velmurugan Ramraj, Grant Barth D, Loerke Dinah, Labbé Jean-Claude

Abstract excerpt

In all organisms, cell polarity is fundamental for most aspects of cell physiology. In many species and cell types, it is controlled by the evolutionarily conserved PAR-3, PAR-6 and aPKC proteins, which are asymmetrically localized at the cell cortex where they define specific domains. While PAR proteins define the antero-posterior axis of the early C. elegans embryo, the mechanism controlling their asymmetric...

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Identifiers

PMID: 22545101
DOI: 10.1371/journal.pone.0035286
PMCID: PMC3335856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RAB-5 controls the cortical organization and dynamics of PAR proteins to maintain C. elegans early embryonic polarity.PMID 22545101Read ↗

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PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.Semantic proximity Read ↗

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