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Article

Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.

Nature cell biology - 1 Aug 2017

Wang Shyi-Chyi, Low Tricia Yu Feng, Nishimura Yukako, Gole Laurent, Yu Weimiao, Motegi Fumio

Abstract excerpt

Cell polarization enables zygotes to acquire spatial asymmetry, which in turn patterns cellular and tissue axes during development. Local modification in the actomyosin cytoskeleton mediates spatial segregation of partitioning-defective (PAR) proteins at the cortex, but how mechanical changes in the cytoskeleton are transmitted to PAR proteins remains elusive. Here we uncover a role of actomyosin contractility in...

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PMID: 28737772
DOI: 10.1038/ncb3577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.PMID 28737772Read ↗

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