Article
CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans.
Current biology : CB - 3 Apr 2001
Kay A J, Hunter C P
Abstract excerpt
BACKGROUND: The polarization of the anterior-posterior axis (A-P) of the Caenorhabditis elegans zygote depends on the activity of the par genes and the presence of intact microfilaments. Functional links between the PAR proteins and the cytoskeleton, however, have not been fully explored. It has recently been shown that in mammalian cells, some PAR homologs form a complex with activated Cdc42, a Rho GTPase that...
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