Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular determinations of EGFR and EML4-ALK on a single slide of NSCLC tissue.

Journal of clinical pathology - 1 Aug 2013

Ulivi Paola, Puccetti Maurizio, Capelli Laura, Chiadini Elisa, Bravaccini Sara, Calistri Daniele, Zoli Wainer, Amadori Dino, Candoli Piero

Abstract excerpt

INTRODUCTION: Tyrosine kinase inhibitors (TKIs) and anti-anaplastic lymphoma kinase (ALK) agents are highly effective for the treatment of non-small cell lung cancer (NSCLC) patients harbouring specific alterations, and molecular characterisation of the tumour is needed even when limited tumour m...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Carcinoma, Non-Small-Cell Lung
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ALK gene

Share to EML4 gene

Share to In Situ Hybridization, Fluorescence

Share to Lung Neoplasms

Share to Oncogene Proteins, Fusion

Source

Identifiers

PMID: 23533259
DOI: 10.1136/jclinpath-2013-201502

Genes

EGFR
ALK
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23533259-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular determinations of EGFR and EML4-ALK on a single slide of NSCLC tissue.PMID 23533259Read ↗

[ALK-Diagnostics in NSCLC - Immunohistochemistry (IHC) and/or Fluorescence-in-situ Hybridisation (FISH)].Semantic proximity Read ↗

Variations in molecular profile in NSCLC can be analyzed using cytological samples: development of EGFR resistance mutations and coexistence of ALK-EML4 translocation in an EGFR-sensitive patient.Semantic proximity Read ↗

Fluorescence In Situ Hybridization, Immunohistochemistry, and Next-Generation Sequencing for Detection of EML4-ALK Rearrangement in Lung CancerSemantic proximity Read ↗

EGFR mutation genotyping and ALK status determination in liquid-based cytology samples of non-small cell lung cancer.Semantic proximity Read ↗

Comprehensive epidermal growth factor receptor gene analysis from cytological specimens of non-small-cell lung cancers.Semantic proximity Read ↗

Increased ALK gene copy number and amplification are frequent in non-small cell lung cancer.Semantic proximity Read ↗

ALK rearrangement in a large series of consecutive non-small cell lung cancers: comparison between a new immunohistochemical approach and fluorescence in situ hybridization for the screening of patients eligible for crizotinib treatment.Semantic proximity Read ↗

A novel mass spectrometry-based assay for diagnosis of EML4-ALK-positive non-small cell lung cancer.Semantic proximity Read ↗

Combined use of ALK immunohistochemistry and FISH for optimal detection of ALK-rearranged lung adenocarcinomas.Semantic proximity Read ↗

Fluorescence In Situ Hybridization and Immunohistochemistry as Diagnostic Methods for ALK Positive Non-Small Cell Lung Cancer PatientsSemantic proximity Read ↗

ALK Status Assessment with Liquid Biopsies of Lung Cancer PatientsSemantic proximity Read ↗

Detection of EML4-ALK fusion genes in a few cancer cells from transbronchial cytological specimens utilizing immediate cytology during bronchoscopy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.