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ALK Status Assessment with Liquid Biopsies of Lung Cancer Patients

12 Aug 2017

Abstract excerpt

Patients with advanced stage non-small cell lung carcinoma (NSCLC) harboring an anaplastic lymphoma kinase ALK gene rearrangement, detected from a tissue sample, can benefit from targeted ALK inhibitor treatment. However, while treatment is initially effective in most cases, relapse or progression occurs due to different resistance mechanisms including mutations in the tyrosine kinase domain of echinoderm...

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PMID: 28805673
DOI: 10.3390/cancers9080106

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