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Article

Combined use of ALK immunohistochemistry and FISH for optimal detection of ALK-rearranged lung adenocarcinomas.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2013

Sholl Lynette M, Weremowicz Stanislawa, Gray Stacy W, Wong Kwok-Kin, Chirieac Lucian R, Lindeman Neal I, Hornick Jason L

Abstract excerpt

INTRODUCTION: ALK gene rearrangements occur in approximately 5% of lung adenocarcinomas (ACAs), leading to anaplastic lymphoma kinase (ALK) overexpression and predicting response to targeted therapy. Fluorescence in situ hybridization (FISH) is the standard procedure for detection of ALK rearrangements in lung ACA but requires specialized equipment and expertise. Immunohistochemistry (IHC) for ALK protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23407557
DOI: 10.1097/JTO.0b013e31827db604
PMCID: PMC3573350

Genes

ALK
BRAF
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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