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Article

[ALK-Diagnostics in NSCLC - Immunohistochemistry (IHC) and/or Fluorescence-in-situ Hybridisation (FISH)].

Pneumologie (Stuttgart, Germany) - 1 Apr 2016

von Laffert M, Schirmacher P, Warth A, Weichert W, Büttner R, Huber R M, Wolf J, Griesinger F, Dietel M, Grohé Ch

Abstract excerpt

The EML4-ALK pathway plays an important role in a significant subset of non-small cell lung cancer patients. Treatment options such as tyrosine kinase inhibitors directed against the EML4-ALK signalling pathway lead to improved progression free and overall survival. These therapeutic options are chosen on the basis of the identification of the underlying genetic signature of the EML-ALK translocation. Efficient...

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Source

Identifiers

PMID: 26984109
DOI: 10.1055/s-0042-102626

Genes

ALK
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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