Article
Increased ALK gene copy number and amplification are frequent in non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jan 2011
Salido Marta, Pijuan Lara, Martínez-Avilés Luz, Galván Ana B, Cañadas Israel, Rovira Ana, Zanui Montserrat, Martínez Alejandro, Longarón Raquel, Sole Francisco, Serrano Sergio, Bellosillo Beatriz, Wynes Murry W, Albanell Joan, Hirsch Fred R, Arriola Edurne
Abstract excerpt
INTRODUCTION: Translocation of the anaplastic lymphoma kinase (ALK) gene is involved in the tumorigenesis of a subset of non-small cell lung carcinomas (NSCLCs) and identifies patients sensitive to ALK inhibitors. ALK copy number changes and amplification, which plays an oncogenic role in tumors such as neuroblastoma, are poorly characterized in NSCLC. We aimed to study the prevalence of ALK copy number changes...
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