ALK rearrangement in a large series of consecutive non-small cell lung cancers: comparison between a new immunohistochemical approach and fluorescence in situ hybridization for the screening of patients eligible for crizotinib treatment.

doi:10.5858/arpa.2013-0388-OA

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Article

ALK rearrangement in a large series of consecutive non-small cell lung cancers: comparison between a new immunohistochemical approach and fluorescence in situ hybridization for the screening of patients eligible for crizotinib treatment.

Archives of pathology & laboratory medicine - 1 Nov 2014

Alì Greta, Proietti Agnese, Pelliccioni Serena, Niccoli Cristina, Lupi Cristiana, Sensi Elisa, Giannini Riccardo, Borrelli Nicla, Menghi Maura, Chella Antonio, Ribechini Alessandro, Cappuzzo Federico, Melfi Franca, Lucchi Marco, Mussi Alfredo, Fontanini Gabriella

Abstract excerpt

CONTEXT: Echinoderm microtubule associated proteinlike 4-anaplastic lymphoma receptor tyrosine kinase (EML4-ALK) translocation has been described in a subset of patients with non-small cell lung cancer (NSCLC) and has been shown to have oncogenic activity. Fluorescence in situ hybridization (FISH) is used to detect ALK-positive NSCLC, but it is expensive, time-consuming, and difficult for routine application....

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Identifiers

PMID: 24885803
DOI: 10.5858/arpa.2013-0388-OA

Genes

ALK
EGFR
EML4
KRAS

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