Article
Comprehensive epidermal growth factor receptor gene analysis from cytological specimens of non-small-cell lung cancers.
British journal of cancer - 15 Jan 2008
Savic S, Tapia C, Grilli B, Rufle A, Bihl M P, de Vito Barascud A, Herzog M, Terracciano L, Baty F, Bubendorf L
Abstract excerpt
Epidermal growth factor receptor (EGFR) gene mutations and increased copy numbers are considered as predictors of response to EGFR tyrosine kinase inhibitors (EGFR-TKI) in non-small-cell lung cancer (NSCLC). Lung cancer diagnosis is often based on cytology alone. However, almost all published data on EGFR gene analyses were obtained from biopsies. This study tested the feasibility of EGFR gene analyses on...
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