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Article

A novel mass spectrometry-based assay for diagnosis of EML4-ALK-positive non-small cell lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2012

Sakai Kazuko, Okamoto Isamu, Takezawa Ken, Hirashima Tomonori, Kaneda Hiroyasu, Takeda Masayuki, Matsumoto Kazuko, Kimura Hideharu, Fujita Yoshihiko, Nakagawa Kazuhiko, Arao Tokuzo, Nishio Kazuto

Abstract excerpt

INTRODUCTION: The presence of the transforming fusion gene echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) in non-small-cell lung cancer (NSCLC) is a predictive marker for the efficacy of anaplastic lymphoma kinase inhibitors. However, the currently available assays for the detection of the different variants of EML4-ALK have limitations. METHODS: We developed an assay...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

Share to Oncogene Proteins, Fusion

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Source

Identifiers

PMID: 22722791
DOI: 10.1097/JTO.0b013e31824c7f7a

Genes

ALK
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel mass spectrometry-based assay for diagnosis of EML4-ALK-positive non-small cell lung cancer.PMID 22722791Read ↗

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