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Article

The TERT Promoter: A Key Player in the Fight for Cancer Cell Immortality.

Biochemistry. Biokhimiia - 1 Jan 2023

Hasanau Tsimur N, Pisarev Eduard P, Kisil Olga V, Zvereva Maria E

Abstract excerpt

The review describes the role of telomeres and telomerase in tumor progression, as well as various mechanisms of the activation of telomerase reverse transcriptase (TERT) expression in CNS tumors and other cancers. The main mechanism of TERT activation involves acquisition of somatic mutations by the TERT gene promoter (TERTp). The article presents information on the TERTp structure and transcription factors...

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Identifiers

PMID: 37069112
DOI: 10.1134/S000629792314002X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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