Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role and regulation of PDGFRα signaling in liver development and regeneration.

The American journal of pathology - 1 May 2013

Awuah Prince K, Nejak-Bowen Kari N, Monga Satdarshan P S

Abstract excerpt

Aberrant platelet-derived growth factor receptor-α (PDGFRα) signaling is evident in a subset of hepatocellular cancers (HCCs). However, its role and regulation in hepatic physiology remains elusive. In the current study, we examined PDGFRα signaling in liver development and regeneration. We identified notable PDGFRα activation in hepatic morphogenesis that, when interrupted by PDGFRα-blocking antibody, led to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Hepatectomy
Share to Hepatocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Regeneration

Share to Platelet-Derived Growth Factor

Share to Proto-Oncogene Proteins c-met

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Tissue Culture Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 23529017
DOI: 10.1016/j.ajpath.2013.01.047
PMCID: PMC3644730

Genes

EGFR
EGF
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role and regulation of PDGFRα signaling in liver development and regeneration.PMID 23529017Read ↗

Role of platelet-derived growth factors in physiology and medicine.Semantic proximity Read ↗

Roles of PDGF/PDGFR signaling in various organsSemantic proximity Read ↗

PDGF receptor signaling networks in normal and cancer cellsSemantic proximity Read ↗

Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis.Semantic proximity Read ↗

A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytesSemantic proximity Read ↗

Platelet-derived Growth Factor Signaling and Human CancerSemantic proximity Read ↗

Insight into the physiological functions of PDGF through genetic studies in mice.Semantic proximity Read ↗

TGF-β serves as a critical signaling determinant of liver progenitor cell fate and functionSemantic proximity Read ↗

EGFR activation in cholangiocytes promotes extrahepatic bile duct regeneration after injurySemantic proximity Read ↗

Autocrine PDGF stimulation in malignancies.Semantic proximity Read ↗

A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin.Semantic proximity Read ↗

The EGF receptor is required for efficient liver regeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.