Article

EGFR activation in cholangiocytes promotes extrahepatic bile duct regeneration after injury

2025-04-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> The epidermal growth factor (EGF) receptor family of tyrosine kinases regulates development and homeostasis of digestive organs including the liver and bile ducts. It consists of four receptors, EGF receptor (EGFR) and erythroblastoma oncogene B 2-4 (ERBB2–4), and their corresponding ligands. EGF signaling promotes intrahepatic cholangiocyte proliferation, bipotent ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64be64e2-7177-5535-9a6c-aab9b9bd7fd3
DOI: 10.1101/2025.04.22.649788

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

EGFR activation in cholangiocytes promotes extrahepatic bile duct regeneration after injuryDOI 10.1101/2025.04.22.649788Read

Mechanism and endoscopic‐treatment‐induced evolution of biliary non‐anastomotic stricture after liver transplantation revealed by single‐cell RNA sequencingSemantic proximity Read

Smad4 restricts injury-provoked biliary proliferation and carcinogenesisSemantic proximity Read

Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regenerationSemantic proximity Read

Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in CholangiocarcinomaSemantic proximity Read

Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.Semantic proximity Read

Hepatocyte Dedifferentiation Profiling In Alcohol-Related Liver Disease Identifies CXCR4 As A Driver Of Cell ReprogrammingSemantic proximity Read

De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiationSemantic proximity Read

Characterization of EGFR family gene aberrations in cholangiocarcinomaSemantic proximity Read

Transcriptome analysis of hepatic fibrosis induced by common bile duct ligationSemantic proximity Read

Farnesoid X Receptor Is Required for the Redifferentiation of Bipotential Progenitor Cells During Biliary‐Mediated Zebrafish Liver RegenerationSemantic proximity Read

Understanding regional diversity in the human biliary tree through transcriptomic profiling of primary tissues and in vitro derived organoidsSemantic proximity Read

Human biliary atresia extrahepatic cholangiocyte organoids express increased ER and oxidative stress, altered drug metabolism and cell polarity changesSemantic proximity Read