Article
Thumb-domain dynamics modulate the functional repertoire of DNA-Polymerase IV (DinB).
Nucleic acids research - 21 Jul 2023
Okeke Damasus C, Lidman Jens, Matečko-Burmann Irena, Burmann Björn M
Abstract excerpt
In order to cope with the risk of stress-induced mutagenesis, cells in all kingdoms of life employ Y-family DNA polymerases to resolve resulting DNA lesions and thus maintaining the integrity of the genome. In Escherichia coli, the DNA polymerase IV, or DinB, plays this crucial role in coping with these type of mutations via the so-called translesion DNA synthesis. Despite the availability of several...
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