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X-ray structure of the complex of regulatory subunits of human DNA polymerase delta

1 Oct 2008

Abstract excerpt

The eukaryotic DNA polymerase delta (Pol delta) participates in genome replication, homologous recombination, DNA repair and damage tolerance. Regulation of the plethora of Pol delta functions depends on the interaction between the second (p50) and third (p66) non-catalytic subunits. We report the crystal structure of p50*p66(N) complex featuring oligonucleotide binding and phosphodiesterase domains in p50 and...

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PMID: 18818516
DOI: 10.4161/cc.7.19.6720

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