Article
Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse.
Developmental biology - 15 Jul 2011
Beyret Ergin, Lin Haifan
Abstract excerpt
PIWI proteins and piRNAs have been linked to transposon silencing in the primordial mouse testis, but their function in the adult testis remains elusive. Here we report the cytological characterization of piRNAs in the adult mouse testis and the phenotypic analysis of Miwi(-/-); Mili(-/-) mice. We show that piRNAs are specifically present in germ cells, especially abundant in spermatocytes and early round...
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