Article
Computational analysis of mouse piRNA sequence and biogenesis.
PLoS computational biology - 1 Nov 2007
Betel Doron, Sheridan Robert, Marks Debora S, Sander Chris
Abstract excerpt
The recent discovery of a new class of 30-nucleotide long RNAs in mammalian testes, called PIWI-interacting RNA (piRNA), with similarities to microRNAs and repeat-associated small interfering RNAs (rasiRNAs), has raised puzzling questions regarding their biogenesis and function. We report a comparative analysis of currently available piRNA sequence data from the pachytene stage of mouse spermatogenesis that sheds...
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